Bone marrow cells in suppressing leukemic cell growth

Seledtsov V.I., Senyukov V.V., Seledtsova G.V., Avdeev I.V., Samarin D.M., Taraban V.Ya., Poveschenko O.V., Morenkov A.V., Kozlov V.A.

Abstract

In this paper we review our experimental findings concerning the capacity of bone marrow cells to control leukemic cell growth. It has been shown that the cells isolated from normal bone marrow can provide dose dependent suppression of the proliferative activity of leukemic cells in vitro.

Bone marrow cells cytostatic effect is antigen non-specific and does not associate with cell death. Cytostatic bone marrow cells differ from mature macrophages, T and B lymphocytes and have the lower floating density. These cells are detected in both aggregated and non-aggregated fraction of bone marrow cells, stimulated by wheat germ agglutinin. During long-term cultivation of bone marrow the cytostatic activity was associated with the radioresistant stromal cells. Both soluble factors and cell-to-cell interactions are involved into the cytostatic process generated by bone marrow cells.

Based on the obtained results, we suggest that the cytostatic activity of bone marrow cells may be increased under the influence of lymphokines, such as IL-2 and IFNgamma.

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