Erythroid cells in suppressing leukemia cell growth

Seledtsov V.I., Seledtsova G.V., Samarin D.M., Senyukov V.V., Poveschenko O.V., Felde M.A., Kozlov V.A.

Abstract

This paper indicates that murine nucleated erythroid cells (EC) are able to reduce, in a dose-dependent manner, the proliferation of both L1210 lymphoma and P815 mastocytoma cells and that the leukemia cell growth inhibitory activity of unseparated bone marrow cells (BM) may be markedly augmented by their short-term culturing with erythropoietin (Epo). These results raise the intriguing possibility to utilize erythropoesis-stimulating, therapeutic strategies with the purpose of inhibiting leukemia cell growth in the body.