­ˇ˝˝ŕŔÚ   english

Osteomyelitis

Treatment

Low-differentiated (stem) cells in plasma clot are implanted into the sterile bone lesion. The treatment is conducted in a surgical department.

Effect

The transplanted cells produce osteogenic growth factors and facilitate bone regeneration.

Infectious safety

Cell material is prepared under sterile conditions.

Side effects

Typical surgical complications are likely.

CELL-BASED TECHNOLOGY FOR CHRONICAL OSTEOMYELITIS

Filling bone defects after removal ţsteomyelitis sequesters remains an important issue. Various compression devices used for this purpose have shown satisfactory results in some cases. However, such treatment requires much time and should be carried out in a hospital environment.

A cell-based treatment modality for osteomielis has been developed based on the administration of fetal-derived or adult bone marrow-derived low-differentiated (stem) cells in plasma clot , which stimulates cell growth. Cell-laden plasma clot is implanted in the sterile bone defect to promote bone regeneration. Such treatment has been found to be safe and well tolerated.

A total of 18 patients with osteomyelitis aged from 18 to 61 years were treated with cell transplants (Table 1).


N DIAGNOSIS PATIENT NUMBER
1 ╬steomyelitis of femur 9
2 ╬steomyelitis of the shin bone (tibia) 7
3 ╬steomyelitis of the sacroiliac articulation (pyogenic sacroiliitis ) 1
4 ╬steomyelitis of sternum 1

Healing was achieved in 10 patients. A positive effect was noted in the 1 remaining patient with osteomyelitis of sternum, who, however, was unable to complete the treatment because of his arresting. Six patients were followed-up over a long period of time (from 1 to 4 years). No cases of disease relapse were noted. These results suggest that the technology, that has been developed in CICT, may be administered effectively for treating osteomyelitis patients.

The examples of applying cell-based technology for chronical osteomyelities are described below.

A 40 year-old female patient underwent osteometalosynthesis by after fracture of the left femur. Posttraumatic osteomyelitis was subsequently developed. For this reason a plate was removed and a framed structure was applied . Later a necrotizing focus (sequestration) of 15 sm long was developed in the shaft of femur (see Figure 1). This focus was resected (see Figure 2) and a brain defect was filled up with a cell implant. Cell transplantation was repeated several times at various time intervals. As a result of such treatment, the secondary clavus was formed (see Figure 3). The patient became able to lean on the left leg and to walk with orthosis.



A 18 year-old male patient P has been operated for reason of hematogenic osteomyelitis of the right femur. After sequestrectomy the cavity with fistula arose in the bone defect (see Figure 4). After several cell implantations the bone defect was lacking (see Figure 5). The patient could walk sufficiently without any help and had no complains.




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