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Osteomyelitis

Treatment

Low-differentiated (stem) cells are placed in the special gel that is implanted into the sanified bone defect. The treatment is conducted in the surgical department.

Effect

The transplanted cells produce osteogenic growth factors, but also participate immediately in bone regeneration.

Infectious safety

The cells designated for transplantation are prepared under conditions excluding their contamination with pathogenic infectious agents.

Side effects

Typical surgical complications cannot be entirely excluded.

Cell-based technology for chronical osteomyelitis

The problem of treating patients with chronical osteomyelitis remains very actual. A cell-based technology of eliminating brain defects has been developed in CICT. Fetal-derived or adult bone marrow-derived, low-differentiated (stem) cells are firstly placed in a special gel favorable to cell growth. The cell-containing gel is further implanted within the sanified brain defect. The implanted cells greatly intensify bone reparation. Such treatment has been found to be safe and well tolerated.

A total of 11 patients aged from 18-to 61 years underwent the cell-based treatment (see Table 1).


N DIAGNOSIS PATIENT NUMBER
1 Chronical hematogenic osteomyelitis of femur 2
2 Chronical posttraumatic osteomyelitis of femur 3
3 Chronical posttraumatic osteomyelitis shank bones 4
4 Chronical posttraumatic osteomyelitis of sternum 1
5 Chronical osteomyelitis sacroiliac articulation (pyogenic sacroileitis) 1

Healing was achieved in 10 patients. A positive effect was noted in the 1 remaining patient with osteomyelitis of sternum, who, however, was unable to complete the treatment because of his arresting. Six patients were followed-up over a long period of time (from 1 to 4 years). No cases of disease relapse were noted. These results suggest that the technology, that has been developed in CICT, may be administered effectively for treating osteomyelitis patients.

The examples of applying cell-based technology for chronical osteomyelities are described below.

A 40 year-old female patient underwent osteometalosynthesis by after fracture of the left femur. Posttraumatic osteomyelitis was subsequently developed. For this reason a plate was removed and a framed structure was applied . Later a necrotizing focus (sequestration) of 15 sm long was developed in the shaft of femur (see Figure 1). This focus was resected (see Figure 2) and a brain defect was filled up with a cell implant. Cell transplantation was repeated several times at various time intervals. As a result of such treatment, the secondary clavus was formed (see Figure 3). The patient became able to lean on the left leg and to walk with orthosis.



A 18 year-old male patient P has been operated for reason of hematogenic osteomyelitis of the right femur. After sequestrectomy the cavity with fistula arose in the bone defect (see Figure 4). After several cell implantations the bone defect was lacking (see Figure 5). The patient could walk sufficiently without any help and had no complains.




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